The INA827AIDGK is a Precision Instrumentation Amplifier that offers extremely low power consumption and operates over a very wide single or dual-supply range. The amplifier is optimized for the lowest possible gain drift of only 1ppm per degree Celsius in G=5, which requires no external resistor. However, a single external resistor sets any gain from 5 to 1000. The amplifier is optimized to provide excellent common-mode rejection ratio (CMRR) of over 88dB (G=5) over frequencies up to 5kHz. In G=5, CMRR exceeds 88dB across the full input common-mode range from the negative supply all the way up to 1V of the positive supply. Using a rail-to-rail output, the amplifier is well-suited for low-voltage operation from a 2.7V single-supply as well as dual supplies up to ±18V. Additional circuitry protects the inputs against overvoltage of up to ±40V beyond the power supplies by limiting the input currents to a save level.