The INA149AID is a precision unity-gain Difference Amplifier with a very high input common-mode voltage range. It is a single monolithic common mode voltage amplifier consists of a precision op-amp and an integrated thin-film resistor network. The INA149 can accurately measure small differential voltages in the presence of common-mode signals up to ±275V. The amplifier inputs are protected from momentary common-mode or differential overloads of up to 500V. In many applications, where galvanic isolation in not required, the amplifier can replace isolation amplifiers. This ability can eliminate costly isolated input side power supplies and the associated ripple, noise and quiescent current. The excellent 0.0005% nonlinearity and 500kHz bandwidth of this amplifier are superior to those of conventional isolation amplifiers.