The AD8208WBRZ is a single-supply Difference Amplifier for amplifying and low-pass filtering small differential voltages in the presence of a large common-mode voltage. The input common-mode voltage range extends from -2 to +45V at a single +5V supply. The amplifier offers enhanced input overvoltage and ESD protection and includes EMI filtering. The AD8208 provides excellent AC and DC performance, minimizing errors in the application. The AD8208 features an externally accessible 100kR resistor at the output of the preamplifier (A1), which can be used for low-pass filtering and for establishing gains other than 20.