The AD8205YRZ is a Single Supply 42V System Difference Amplifier for amplifying small differential voltages in the presence of large common-mode voltages. The operating input common-mode voltage range extends from -2 to +65V. The typical single supply voltage is 5V. Excellent DC performance over-temperature keeps errors in the measurement loop to a minimum. Offset drift is typically less than 15μV/°C and gain drift is typically below 30ppm/°C. The output offset can be adjusted from 0.05 to 4.8V with a 5V supply by using the VREF1 and VREF2 pins. With VREF1 attached to the V+ pin and VREF2 attached to the GND pin, the output is set at half scale. Attaching both pins to GND causes the output to be unipolar, starting near ground. Attaching both pins to V+ causes the output to be unipolar starting near V+. Other offsets can be obtained by applying an external voltage to the VREF1 and VREF2 pins.